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What is Scleroderma the role of Cannabidiol

What is Scleroderma the role of Cannabidiol

Scleroderma is a rare and serious disease that affects around 10,000 people in France. It is also known as systemic scleroderma . It can be a devastating disease that leads to significant injury, disability and reduced life expectancy. This will be a review of using CBD for scleroderma as a way to manage discomfort.

Although there is no cure for scleroderma, it can be controlled with medication. In many cases, scleroderma can be relieved with medication. It's not always the case. A promising new treatment is CBD for scleroderma.

Although more research is needed, CBD oil may give new hope to people with scleroderma.

What is scleroderma?

Scleroderma is an exceptionally rare autoimmune disease in which the body produces too much collagen. This excess collagen leads to hardening and thickening of the skin and organ damage.


Scleroderma can be systemic or localized. Systemic scleroderma affects the whole body , while localized scleroderma affects only one area of ​​the body . Symptoms and severity of the disease vary from person to person, and scientists aren't sure exactly what causes the condition.

Finger scleroderma?

The care protocols are multidisciplinary and treat symptoms that affect many organs of the body, because it can be a difficult disease to treat and difficult to live with on a daily basis.

But with a little support and awareness, you can feel more comfortable in your own skin and relieve common symptoms like pain, fatigue, and deficiencies.

What is CBD?

Cannabidiol (CBD) oil is produced from the cannabis plant and has been shown to have anti-inflammatory and immunomodulatory effects. Additionally, CBD oil effectively reduces anxiety and pain in various conditions.


CBD in cannabis?

CBD is called cannabidiol , it is simply a plant molecule. Cannabis has many cannabinoids, which are more than 120. With each passing day, we are learning more and more about these natural molecules.

Symptoms of scleroderma?

Scleroderma can manifest in different ways, ranging from mild to severe and even life-threatening. The severity of symptoms is determined by the areas of the body affected and the extent of the disease.


Scleroderma is a disease that attacks the skin and causes an unusual skin condition that becomes thick and hard. It is associated with tissue hyperplasia, which can damage your internal organs.

Scleroderma comes in two forms. Each type affects symptoms and affected areas differently. Here are the two varieties, as well as their characteristics:

  • Localized scleroderma

Localized scleroderma is usually insignificant. Although it mainly affects the skin, it can also spread to joints, muscles and bones. It rarely becomes a systemic disease, although it sometimes affects internal organs.

While localized sclerosis does not usually affect internal organs, diffuse sclerosis can cause diffuse systemic sclerosis fibroblasts to produce excess collagen in every organ of the body.

As a result, patients with scleroderma can experience organ damage, including heart, lung, and kidney problems. Diffuse sclerosis is considered a more serious form of scleroderma because it can be life-threatening.

  • Systemic sclerosis

Systemic sclerosis is a chronic, progressive and rare autoimmune disease that affects connective tissue in many parts of the body, joints, muscles, bones, blood vessels, heart, gastrointestinal tract, esophagus, lungs, kidneys and skin.

Systemic sclerosis can cause excessive amounts of collagen and scarring to develop in the lungs (interstitial lung disease), leading to narrowing and blockage of the arteries in the lungs (pulmonary hypertension).

There are two types of systemic sclerosis:

  • Limited scleroderma

Limited scleroderma usually affects the skin and muscles of the arms and face and can cause Raynaud's phenomenon, in which blood vessels in the fingers and toes constrict in response to cold or The exact source of limited scleroderma is not not known, but it is most likely the result of an autoimmune reaction that leads to excess collagen production. Additionally, exposure to certain chemicals is associated with this condition in certain circumstances.

  • Diffuse scleroderma

Diffuse scleroderma affects internal organs such as the gastrointestinal tract, heart, and lungs. Patients with scleroderma often experience fatigue, pain and stiffness in the joints, Raynaud's phenomenon and difficulty swallowing. Unfortunately, systemic sclerosis is not curable, but there are treatments that help control symptoms and slow the progression of the disease.

CBD in scleroderma?

Scleroderma is a disease that affects connective tissue and internal organs, accompanied by hardening and thickening of the skin. Diagnosing it can be difficult because it has common symptoms with other conditions, but recent studies have shown that CBD can effectively treat patients with scleroderma because CBD helps manage discomfort.

CBD oil drops

CBD oil is known to help relieve chronic pain, inflammation, anxiety, and insomnia, which are common symptoms of scleroderma. Additionally, CBD oil may help improve the quality of life for scleroderma patients by reducing the severity of these symptoms.

Anti-inflammatory effects of CBD

CBD appears to have potential anti-inflammatory effects. This is great news for anyone with scleroderma or other painful conditions, as inflammation is a major cause of pain.

Scleroderma is a condition characterized by the hardening of dilated blood vessels in the fingers.

Unfortunately, there is no cure for scleroderma, but CBD can help treat symptoms.

Apply CBD Cream

One study found that CBD could reduce inflammation in rats with scleroderma. The study authors believe that CBD works by inhibiting fatty acid amide hydrolase – an enzyme that plays a role in inflammation. According to preliminary studies, CBD shows promising results as a treatment for scleroderma and other inflammatory diseases.

Is CBD safe?

CBD is a safe, natural drug with few side effects, making it ideal for treating patients with systemic sclerosis.

How can CBD help with scleroderma? What are the benefits?

CBD has an antifibrotic effect in scleroderma. It also helps reduce other symptoms such as inflammation, insomnia, pain, as well as respiratory and gastrointestinal issues.

Additionally, the many healing properties of CBD can help prevent complications that can occur with scleroderma, while promoting healthy skin renewal.

Despite the fact that few human studies have examined the effects of CBD on scleroderma, the research is promising.

For example, a 2006 animal study showed that topical application of CBD reduced skin thickness and improved skin function in rats with scleroderma. A similar 2016 study looked at the effects of CBD on intestinal fibrosis and found that CBD was able to reduce inflammation and oxidative stress.


CBD may also affect internal organs associated with systemic sclerosis by reducing oxidative damage. For example, in a 2017 mouse study, researchers found that CBD helps reduce inflammation and fibrosis in the lungs of mice with scleroderma.

CBD has also been found to reduce pain and insomnia , two common symptoms that people with scleroderma face.

Despite the fact that there are still many studies to be done to determine the effectiveness of CBD in the treatment of scleroderma, the existing evidence suggests that it could be a useful addition to existing treatments.

Role of CBD in autoimmune diseases

According to a 2016 study examining the role of CBD in autoimmune diseases, CBD has an immunosuppressive effect. CBD is very effective at restricting the movement of leukocytes and inducing cell death (apoptosis), while reducing the production of cytosines, which cause inflammation.

Patients with systemic sclerosis have seen reduced levels of CBD and increased positive outcomes, including better quality of life, reduced pain, and reduced inflammation.

The study also found that CBD helps reduce other symptoms such as fatigue, muscle aches, and morning stiffness. Additionally, CBD has an antifibrotic effect in scleroderma, helping to reduce collagen buildup, which can lead to fibrosis.

In conclusion , the researchers concluded that CBD effectively treats various autoimmune diseases and offers a safe and natural alternative to traditional medications.

Scleroderma and the endocannabinoid system

The endocannabinoid system is a potential target for scleroderma drugs for several reasons. On the one hand, scleroderma fibroblasts overexpress both cannabinoid receptor subtypes. Additionally, the amount of FAAH, a metabolic enzyme that breaks down the endocannabinoid anandamide, is significantly reduced in the skin of scleroderma patients.

This suggests that the endocannabinoid system is out of balance. Nevertheless, the endocannabinoid system plays a role in rheumatic diseases and targeted drugs could relieve inflammatory pain.

Additionally, because the endocannabinoid system is located in the central nervous system, using medications directed at it can help relieve various symptoms associated with scleroderma, such as fatigue and sadness. Therefore, the endocannabinoid system is a promising target for the future treatment of scleroderma.

Video " how the endocannaibinoid system works"

THC and fibrotic effects

Cannabinoid receptors are located throughout the body, with two main subtypes CB1 and CB2. Cannabinoids, such as CBD and THC, play a vital role in maintaining the balance between pro and anti-fibrotic properties, which are essential for keeping the body healthy

brain receptors

Cannabinoid receptors are found throughout the body and in the skin. Skin diseases usually involve an overproduction of collagen, the main skin protein.

The body produces excess collagen to strengthen the skin, but this often leads to the buildup of scars. Cannabinoid receptor subtypes are thought to play a role in regulating collagen production.

This balance is disturbed in conditions such as fatty liver disease and certain skin diseases, and excess connective tissue begins to develop. Excess tissue can lead to serious problems, poor quality of life and suffering for patients.

CBD can have an antifibrogenic or profibrogenic effect in the liver, both of which are cannabinoid receptor subtypes. Additionally, CBD has been shown to cause such results.

The good news is that targeting these receptors can restore balance and improve symptoms. More research is needed to confirm this, but the potential benefits are promising.

In conclusion :

Scleroderma is a rare disease that can be difficult to diagnose and treat, especially because it doesn't seem to have a specific cause. Although CBD has not been studied in detail in scleroderma, several doctors and experts have called for its use to relieve symptoms and reduce pain and inflammation .

CBD may work by reducing pain in the peripheral nervous system, keeping connective tissue healthy, and reducing inflammation in the body. Additionally, medical cannabis is an effective treatment for other chronic conditions such as chronic pain, multiple sclerosis and more.

If you suffer from this disease and are looking for an alternative treatment, CBD is a good option and there is a wide range of hemp-derived products that meet the specific needs of the whole body. Try several different products to see which works best for you and your condition.


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