Cannabidiol (CBD) is a compound found in cannabis that can be isolated and used therapeutically. CBD is considered a non-psychoactive cannabinoid, meaning it does not produce the euphoric/psychotropic effects associated with marijuana use. Instead, CBD is often used to treat a variety of symptoms and conditions, including nausea, pain, anxiety, muscle spasms, and trouble sleeping.
CBD is generally considered safe and well tolerated, but it can cause some rashes, headaches, and dizziness. Additionally, some people are allergic to CBD. If you are allergic or experience any adverse side effects, stop taking CBD and consult your doctor.
What is CBD and how does it work?
Cannabidiol (CBD) is a molecule or cannabinoid found in the Cannabis Sativa plant. There are several varieties of cannabis plants, including industrial hemp and marijuana.
Although CBD can be obtained from any of these plants, it is more commonly obtained from industrial hemp, where it is much more common than marijuana.
Unlike its related cannabinoid, THC, cannabidiol is not psychoactive, meaning it won't get you drunk.
The CBD used in our products is derived from hemp and none of our products contain THC.
CBD How does it work?
Much research is currently underway on this issue. We now know of two main modes of action of CBD in the body (further study of these mechanisms will certainly continue to reveal more):
Stimulates our endocannabinoid system (ECS) - This sympathetic system was only discovered by scientists in the early 90s of the last century.
SEC refers to a collection of cellular receptors and related molecules. You can think of cell receptors as little locks on the surface of cells.
The keys to these locks are chemical molecules called agonists. Each time the agonist connects to the cell, it transmits a message, giving your cell a specific direction.
The endocannabinoid system is the name for a series of cell receptors that respond to certain types of agonists.
Two major cell receptors are ECS - cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).
The key substances in these receptors are called endocannabinoids, which are essentially the body's own version of THC and CBD (which are phytocannabinoids).
Cannabinoid receptors
are found all over the body, including the skin, giving them a wide variety of functions. However, some receptors are more concentrated in certain regions.
- CB1 receptors are numerous in the central nervous system.
- CB2 receptors are most common on immune cells, in the gastrointestinal tract, and in the peripheral nervous system.
The ECS plays an important role in neuroprotection, stress recovery, immune balance and homeostatic regulation (maintaining a stable internal environment). When CBD binds to these receptors, a mechanism is triggered in the ECS that triggers a wide range of therapeutic and healing responses.
Helps regulate key bodily functions
So far, CBD is known to act directly or indirectly on three other receptors (vanilloid, adenosine, and serotonin), which are important in modulating pain, the sleep-wake cycle, and mood and stress management.
It is also associated with an increase in the natural "happiness molecule" - anandamide, which helps regulate functions such as pleasure, appetite, memory, sleep and pain.
What are the potential side effects of CBD?
The most talked about side effects of CBD are drowsiness, gastrointestinal issues, dry mouth, decreased appetite, nausea, and interactions with other medications. They are described in detail below.
Some common side effects of using CBD include drowsiness and sedation. This is also considered a benefit, the effect may be too strong if you take CBD with other sedatives.
- CBD VS Gastrointestinal Issues
Some people may experience diarrhea or liver problems. It depends on the individual and their medical history, so monitoring is important”
Also known as "pasty mouth", CBD can potentially cause a very dry feeling in the mouth and eyes.
- CBD VS interaction with other drugs
CBD can interact with certain medications. It's important to talk to your doctor about whether CBD may affect your existing prescriptions.
In some cases, those taking CBD supplements may experience nausea. It depends on how sensitive the person is to Cannabidiol, as well as how much they ingest.
Since CBD supplements come in many different forms – such as oils, capsules, Flowers and vaporizers – the amount actually absorbed can vary widely.
This, combined with an individual's unique biochemistry, will ultimately affect what (if any) CBD side effects you may experience.
Cannabidiol (CBD) is toxic?
CBD is not an intoxicant, while THC is a psychoactive substance that can put you to the test.
CBD is derived from hemp and is classified as a legal substance. Hemp that contains CBD is not regulated by the ANSM and therefore doses may not be exact.
It is also difficult to know what the correct dose is when trying a new product for the first time.
Choose CBD from a trusted source that has been tested by an independent third-party lab, the CBD content is more reliable and safe.
Are there any benefits associated with using CBD?
There are several reasons why someone might want to use CBD. The substance can be found in many products, ranging from oils to CBD creams for skin care. Research is still ongoing, but over the past few decades scientists have realized just how useful CBD can be when applied topically or ingested.
Since the discovery of the endocannabinoid system (ECS) in the body in the 1990s, CBD has been studied more extensively. SEC is a central regulatory system that restores normal balance and homeostasis in many human physiological systems of the body and brain.
As with any type of supplement, we recommend consulting your doctor to find out if using CBD is right for you. Your doctor can also recommend certain products for your needs and help you make sure you're getting the right dose.
CBD against cardiac indication?
As for heart problems, they are incompatible with the use of CBD. There is a clear contraindication, especially at high doses. In fact, cannabidiol can sometimes cause adverse effects, in some cases harmful to the sensitive cardiovascular system. In addition, people with Parkinson's disease should seek advice from their doctor regarding products containing cannabidiol. Finally, there is an absolute contraindication that should be respected in people allergic to pollen of the botanical species Cannabis Sativa L.
CBD and pregnancy against indication?
CBD has been shown to have a significant effect on the female reproductive system if used for a long time during pregnancy. CBD generally affects pregnancy by interfering with the normal development of fetal organs.
The exact mechanism by which this occurs is not yet known to science. However, this was confirmed experimentally by administering CBD to rats. CBD use in pregnant rats has also been found to reduce fetal growth rate and delay sexual maturity later in life. This indicates the potential side effects that cannabidiol use may have if used for long periods of time in pregnant and/or breastfeeding women.
CBD and Hypertension against indication?
Combining CBD with other blood pressure medications is the biggest potential issue if you plan to use CBD to lower or control your blood pressure .
If you are already taking medication for high blood pressure, combining them with CBD may cause your blood pressure to drop too low. You should know that very low blood pressure is just as deadly as very high blood pressure.
Therefore, you should consult your doctor before combining CBD with medications you are already taking. Your doctor may reduce the dose of blood pressure medication you are taking before allowing you to incorporate CBD oil or CBD medications into your daily routine.
CBD and drug interactions
Studies to date have shown that CBD is generally safe and has few, if any, minor side effects. But there is one big caveat: CBD has the potential to interact with certain medications. The concern relates to how the body metabolizes certain substances.
Before trying CBD, it is extremely important to tell your doctor about all prescription and over-the-counter vitamins, supplements, and medications you are taking. Here's a more in-depth look at the importance of having a conversation.
Metabolism of CYP450 drugs and enzymes
Drug metabolism takes place throughout the body, for example in the intestines, but the liver also does a lot of the work.
A family of enzymes called cytochrome P450 (CYP450) see study , do important work in converting foreign substances so that they can be easily removed from the body.
However, some drugs or substances affect CYP450 by slowing or speeding up drug metabolism. This change in your metabolic rate can change the way your body processes the medications or supplements you are taking hence drug interactions.
Studies show that the CYP450 family of enzymes is responsible for the metabolism of several cannabinoids, including CBD.
In particular, this task is carried out by CYP3A4, an important enzyme of the CYP450 family. But CBD also interferes with CYP3A4 during this process.
The CYP3A4 enzyme is responsible for the metabolism of approximately 60% of clinically prescribed drugs. But if CBD inhibits CYP3A4, it may not be as effective at breaking down drugs in your body.
The reverse can happen. Many drugs inhibit CYP3A4. If you then take CBD while on these medications, your body may not be able to process the CBD as effectively.
How to take CBD with medication?
If you'd like to try CBD as an adjunct therapy to relieve symptoms of a particular condition, talk to your doctor first.
It can help you determine which CBD product, dosage, and schedule is safe for your medications. In some situations, your doctor may want to monitor your plasma levels of certain medications you are taking.
Do not stop any of your medications to try CBD unless your doctor tells you it is safe.
Keep in mind that topical application of CBD, such as lotions, creams, and balms, may also be an option.
Unlike oils, edibles, and e-liquid or herbal vaporizers, topical agents generally do not enter the bloodstream - unless it is a transdermal solution designed for this purpose.
Potential Drug Interactions
While research is still ongoing to determine potential interactions between CBD and specific medications, there is one rule that may help users in the meantime: Avoid CBD if there is a grapefruit warning on the label. of your medicine.
According to the Food and Drug Administration , a trusted source, consuming grapefruit while taking any of these medications may result in higher drug levels.
More than 85 drugs interact with grapefruit and certain nearby citrus juices - such as Seville oranges, pomelo and tangelo. The result is a delayed metabolism of the drug.
Grapefruit warnings are common in several types of medications, but not all medications in a given category will require grapefruit to be avoided. Check the information in the leaflet for your medicine or ask your doctor for advice.
Types of Medications That Often Have a Grapefruit Warning
- antibiotics and antimicrobials
- cancer drugs
- antihistamines
- antiepileptic drugs (AEDs)
- blood pressure medication
- drugs for ra
- anticoagulant
- cholesterol medications
- corticosteroids
- drugs for erectile dysfunction...
non-exhaustive list ask your doctor for advice.
Ongoing Drug Interaction Studies
Researchers are working to determine specific interactions between CBD and different medications. Animal studies have been done on some drugs, but in many cases scientists are still finding
Safety and Side Effects
Under the close supervision of your doctor, you may be able to safely use CBD with medications, even those with a grapefruit warning.
He may also choose to monitor your liver function.
If you are taking CBD with medication, it is important to monitor any changes in how the medication or CBD affects you.
Side effects to watch out for:
- drowsiness
- sedation
- nausea
a decrease in the effectiveness of medications, such as:
common side effects of CBD, such as:
- fatigue
- diarrhea
- appetite changes
- weight changes
conclusion on contraindications and CBD
It is important to always consult your doctor first if you wish to try CBD, especially if you have the disease and are taking medication. Do not stop taking your prescribed medications to try CBD unless you have the green light from your doctor.
"Grapefruit" warning medications may interact with CBD. However, even if you are taking one of these medications, your doctor can work out a plan for you by carefully monitoring the drug levels in your body. This way you can use both your prescription and the CBD as therapy.
Your doctor or trusted salesperson can also recommend a quality CBD product for your needs. You can also find reliable products with a little research and knowledge to learn how to read CBD labels.
