Chronic neuropathic pain affects hundreds of millions of adults worldwide and has a direct impact on quality of life. This pathology is characterized in detail in terms of cellular and molecular mechanisms, and the endocannabinoid system (dry) is largely recognized as the key to the development of chronic neuropathic pain.
Scientific evidence confirms that phyto-synthetic and endocannabinoids are effective in the treatment of pain, while there are solid data on the therapeutic use of cannabis derivative products. Here we review the involvement of dry, as well as other cellular and molecular elements, in the pathology of chronic neuropathic pain and how this system can be targeted to treat pain.
Chronic neuropathic pain ?
Chronic pain is classified by the International Association for the Study of Pain (IASP) as pain that lasts more than 3 months, even after the healing of the underlying cause (Raja et al., 2020). One of the main types of chronic pain is neuropathic pain, which occurs when pain is caused by a lesion or disease of the somatosensory nervous system (Raja et al., 2020).
Patients can undergo both social and economic consequences, as it is very annoying to perform daily tasks when they suffer. Physical and social disabilities, as well as pain, can sometimes lead to depression.
Although opioids are the main pharmacotherapeutic approach to reduce the symptoms associated with chronic neuropathic pain, a certain number of reports have described their dependence potential and consequently an increase in mortality (Hser et al., 2015).
To avoid side effects similar to those caused by opioids and to obtain greater success in the treatment of pain, new molecular targets for the treatment of chronic neuropathic pain are constantly under study.
The role of Endocannabinoide system As a pharmacological target and the benefits of using medical cannabis SP. for pain treatment are remarkable, as described in This review. However, additional research is needed with animal models and in clinical practice to understand more effective means of modulating DHWs in humans and to identify how the concomitant effect can contribute to the cannabis SP treatment potential. in pain treatment.
What CBD to fight pain?
CBD oil comes from the cannabis plant. CBD products generally do not contain tetrahydrocannabinol (THC), which is the intoxicating ingredient that people associate with cannabis. When the product contains THC, its quantities are generally very low.
Researchers study the effectiveness of CBD oil under many conditions, including chronic pain. Research is also underway on the safety of CBD products.
It can be difficult for people to choose a safe product with CBD oil due to the lack of coherent regulation. Some studies from a reliable source show that certain products are not properly labeled and may include ingredients or unexpected quantities.
Neuropathy cause, treatment, medication?
Neuropathy is a condition of chronic pain. A person with neuropathy has damaged nerves.
Damaged nerves may occur after a physical traumatic accident or in several different conditions. such as :
- deficiency in certain nutrients
- chronic alcohol abuse
- Diabetes
- Infections
- inflammatory conditions such as vasculitis
- low levels of thyroid hormones or hypothyroidism
Sometimes doctors cannot determine the cause of neuropathy, but they can suggest different treatment options.
If a person develops neuropathy from treatable conditions, such as diabetes, chronic alcohol abuse or nutrient deficiencies, the doctor will first seek to control the disease.
People with pain chronic neuropathy can benefit from the consultation of a pain specialist if regular pain relievers do not work.
Doctors can prescribe drugs, such as:
- membrane stabilizers, including gabapentine
- antiepileptics, including phenytoin
- tricyclic antidepressants, including amitriptyline
How can CBD relieve neuropathic pain?
Sometimes, treatments in current directives do not provide sufficient relief from pain, and we can prefer to study the CBD oil For neuropathy for its painkillers
In a Small on Pubmed Study 2020, a reliable source, the researchers randomized 29 people with neuropathy to receive CBD oil or a placebo.
Participants of the CBD oil group have tolerated the product well and had a statistically significant reduction in pain compared to the placebo group.
Although these results seem promising, researchers must conduct additional studies with a wider population to confirm these results.
People with neuropathy say that several cannabis products, including unhale -based cannabis, sprays and tablets, are effective.
However, there is still a lack of solid evidence that any CBD product works in chronic neuropathic pain
The risks linked to the consumption of cannabidiol oil for pain
The risks linked to the use of CBD oil include the possibility of erroneous labeling, exposure to higher doses of THC or other contaminants.
The FDA is studying the health allegations offered for CBD products. They suggest that CBD products can potentially harm consumers, in order to avoid contaminated products always choose a serious reseller that offers third -party laboratory tests to guarantee the content of healthy and legal cannabis oil.
What CBD cannabis to improve neuropathic pain?
Apply a Cannabidiol Balm (CBD) on the painful area or take it by oral track Can help relieve pain from neuropathy. However, additional research is necessary to prove the effectiveness of CBD and painkillers.
How to use CBD for pain?
Cannabis has been used in the long term in treatment as painkiller, spasticity, nausea and anxiety. It is also used to relieve the symptoms of Irritable colon syndrome, epilepsy, Parkinson's disease and multiple sclerosis.
Cannabidiol exists in different form in order to relieve your pains such as oils, capsules, liquids, patches or even creams or balms with cannabis ...
What is the most effective CBD?
Non -psychotropic CBD or cannabinoid is a component of hemp, marijuana and other cannabis varieties. It is the most effective in the treatment of neuropathic pain.
You will have to try different dosage From cannabidiol because each person reacts differently at the function of their physiology and biology, but the most commonly used shape is CBD oil.
Is the CBD legal?
The original CBD products of hemp and containing less than 0.2% THC are legal in France. On the other hand, CBD products derived from cannabis are legal. Check local laws, especially when traveling.
How to fight against neuropathic pain?
Some doctors recommend Transcutaneous electric nerve stimulation (tens) as a non -invasive treatment to relieve the pain of neuropathy. Tens uses electric current to activate the nerves to relieve the pain.
Some people prefer to use plant remedies. Some of the remedies that scientists have studied for neuropathy, in particular:
- Acorus Calamus
- Alstonia Scholaris
- Citrullus Colocynthis
- Turmeric Longa
- Crocus sativus
- Ginkgo Biloba
- Special Mitragyna
- Momordica Charantia
- Salvia officinalis
CBD and fibromyalgia
The use of CBD to treat fibromyalgia is controversial. Some practitioners recommend the use of CBD to relieve neuropathic pain because it has an anti-inflammatory and anti-spasmodic effect.
Read our article on fibromyalgia To know more ...
Consult your doctor
Before using products containing CBD oil, you must consult a doctor, as some products may affect or interact with other drugs.
Doctors can help individuals, but they cannot guarantee the effectiveness of CBD products in neuropathy. By discussing the use of CBD with a doctor, you can monitor any potential side effects.
If the person with neuropathy is looking for alternative treatment, the doctor can help him find a more appropriate option. By discussing therapeutic objectives and perceived advantages of the use of CBD oil, doctors can help set reasonable objectives for pain relief and set realistic expectations.
Summary
Although many people with neuropathy explore the possibility of using CBD -based products, there is no evidence of their effectiveness.
People with neuropathy who think they do not feel enough pain relief thanks to traditional therapies should talk to their doctor.
