Imagine such intense pain that it is nicknamed "the pain of suicide". It is the daily life of people suffering from bunch headache, a rare but extremely painful neurological disorder. Today, a natural molecule arouses hope: the psilocybin, the active principle of hallucinogenic fungi.
Capphalés in cluster and the promise of psilocybin
Recent studies, such as that carried out by the University of Yale, suggest that the Psilocybin in microdosage could reduce the frequency and intensity of crises. But how could this substance work, and could it surpass conventional treatments?
In this article, we explore the causes of bunch headache, the limits of current drugs, and scientific evidence behind the psilocybin as potential treatment. We will also discuss the role of CBD, another natural alternative studied for pain management.
Note : In France, psilocybin remains illegal outside the authorized medical framework. This article has an informative aim and does not promote its unregulated use.
Capphalés in cluster: Symptoms and causes
Capphalé symptoms in cluster
THE bunch headache (or "vascular algia of the face") are characterized by:
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Extreme unilateral pain, often located around the eye or the temple.
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Frequent and cyclical crises, occurring in "clusters" (several times a day for weeks).
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Associated symptoms : Labs, nasal congestion, agitation.
These crises, lasting 15 minutes to 3 hours, are so intense that they can seriously handicap the quality of life.
Neurological causes and mechanisms
Researchers suspect a Hypothalamus disruption, an area of the brain involved in biological rhythms. Other factors include:
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Salta imbalances, a key neurotransmitter in the modulation of pain.
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Genetic factors, with family history in some cases.
Classic treatments: efficiency and limits
Currently, medical options include:
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High speed oxygen therapy (Pure oxygen inhalation) - effective but bulky.
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Triptans (injectable or nasal) - Relieve quickly but can cause side effects (nausea, dizziness).
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Corticosteroids and antiepileptics - Used in prevention, but with long -term risks.
Despite their usefulness, these treatments do not work for everyone and present accessibility and cost constraints.
Psilocybin: Studies and microdosage
An inspiring natural alternative
There psilocybin, known for its psychedelic effects, acts on receptors serotonergic (5-HT2A), potentially involved in the bunch headache.
Scientific evidence
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Yale study (2021) : Microdosage patients have reported 50 % reduction in crises.
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Anecdotal reports : Some patients feel sustainable relief after a single dose.
Precautions and legality
In France, psilocybin is prohibited outside clinical trials. Its use must be supervised To avoid psychiatric or cardiovascular risks.
Comparison: vs psilocybine vs cbd drugs
| Treatment |
Efficiency |
Side effects |
Accessibility |
| Triptans |
Fast, but variable |
Nausea, fatigue |
Prescribing |
| Oxygen therapy |
Very effective |
Little side effects |
Expensive |
| Psilocybin |
High potential (current studies) |
Psychedelic risks |
Illegal (excluding medical framework) |
| CBD |
Partial relief (painkiller) |
Light, well tolerated |
Legal, easy to access |
Conclusion: towards new solutions?
There psilocybin represents a fascinating track for bunch headache, but wider studies are necessary. In the meantime, conventional treatments and CBD (legal and non -psychoactive) offer alternatives.
Sources and references
