CBD (cannabidiol) is often touted as a natural and safe product, but a recent FDA study published in JAMA Internal Medicine nuance this perception. This rigorous research reveals that cannabidiol may cause cannabidiol liver damage in some people, even at commonly consumed doses.
For the millions of CBD users in France and elsewhere, these results highlight the importance of an informed and careful approach. As specialists in the sector for several years, at CBDtech, we believe in transparent information for responsible consumption.
Study methodology: a rigorous scientific approach
A Randomized, Double-Blind, Placebo-Controlled Study
To understand the true significance of these findings, it is essential to understand how the study was conducted. This is a randomized, double-blind, placebo-controlled study - considered the gold standard in clinical research.
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Participants : 201 healthy adults with no history of liver problems
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Dosage : 5 mg/kg/day of CBD, equivalent to approximately 350 mg per day for a 70 kg person - a high dose -- Fabien from CBDtech recommends a maximum dosage of 50mg/day using our quality controlled CBD oils
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Duration : 4 weeks of treatment followed by an observation period
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Groups : Random distribution between CBD group and placebo group
This robust methodology allows observed effects to be attributed specifically to CBD, and not to other factors.
Key Results: What the CBD Liver Risk Study Reveals
Significant elevations of liver enzymes
The most striking results concern the impact of CBD on markers of liver function:
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5.6% of participants on CBD had elevated liver enzymes (ALT/AST) exceeding 3 times the upper limit of normal
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0% in the placebo group did not show such elevations
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7 cases met criteria for potentially drug-induced liver injury
Temporal and demographic characteristics of CBD effects on the liver
The study also made it possible to identify important patterns:
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Appearance time : The elevations appeared after approximately 21 days of treatment
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Resolution : Values normalized within 1 to 2 weeks after stopping CBD
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Gender predisposition : The effects were mainly observed in women
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Suspected mechanism : The presence of eosinophilia suggests an immune mechanism rather than direct toxicity
Please note: The study did not detect any significant impact of CBD on male hormones or thyroid function, confirming its safety profile on these specific aspects.
Implications and risk factors: who should be particularly vigilant?
Understanding risky contexts
While these results do not mean that CBD is dangerous for everyone, they do identify situations requiring increased caution:
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Concomitant consumption with other hepatotoxic drugs
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History of liver problems even light
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Prolonged use beyond 3 weeks without supervision
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High doses greater than 5 mg/kg/day
Balance and perspective: CBD remains beneficial when used correctly
Don't throw the baby out with the bath water
These results do not call into question all the documented benefits of CBD, but remind us that no active substance is devoid of potential side effects. Thousands of studies and testimonials support the usefulness of CBD for various conditions when used judiciously.
Discover our certified CBD capsules and precisely dosed for safe use
The importance of quality and advice
At CBDtech, we insist on:
- The transparency of dosages to avoid unintentional overconsumption
- The purity of products without contaminants that could worsen liver risks
- Thepersonalized support to adapt the dosage to each profile
Practical recommendations for responsible consumption
Consult your doctor before use
This study reinforces the importance of:
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Chat with a healthcare professional before starting CBD supplementation, especially in case of concomitant drug treatment
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Monitor your liver function by blood tests if you consume CBD regularly in moderate to high doses
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Favor progressiveness starting with low doses
Take a “less is more” approach
Moderation remains key:
- Use the minimum effective dose rather than routine megadoses
- Take periodic breaks if you use CBD daily
- Keep a diary of your symptoms and possible side effects
Conclusion: towards informed consumption of CBD
This FDA study published in JAMA Internal Medicine marks a turning point in our understanding of the safety profile of CBD. She reminds us that cannabidiol, like any active substance, requires respect and precautions. The cannabidiol liver damage although rare, are possible and must be known to consumers.
The responsible approach that we defend at CBDtech consists of:
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Continuously inform yourself on scientific advances
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Favor quality products with independent analyzes
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Consult professionals for use adapted to your situation
CBD remains a valuable tool for many when used judiciously. Continue to stay informed on our blog to deepen your knowledge.
