As our knowledge of cannabinoids increases, so does our understanding of cannabis. Other lesser-known cannabinoids, such as CBG , are already attracting the attention of scientists and consumers.
According to preclinical studies , CBG and CBD may have many therapeutic properties. CBG and CBD are non-psychoactive cannabinoids that may possess antioxidant, neuroprotective, and analgesic activities.
In combination, CBD and CBG may provide powerful anti-inflammatory benefits for the treatment of neuroinflammation
But where do their similarities end? CBG differs from CBD in several ways, as a closer look reveals. But how ?
WHAT IS CBG?
CBG is short for cannabigerol. Cannabigerol is one of over 120 cannabinoids found in cannabis and was first isolated in 1964.
Research on CBG is still in the preclinical stage, but available studies show that it has significant therapeutic promise.
The analgesic properties of CBG can surpass those of THC without achieving an intoxicating effect. There is also some evidence that CBG may offer anticancer, antidepressant, and antibacterial properties.
Cannabigerolic acid (CBGA) is the precursor of the cannabinoids THC, CBD, CBC. As the cannabis plant matures and grows, enzymes convert CBGA into the three main cannabinoid acids: tetrahydrocannabinolic acid (THCA), cannabidiol acid (CBDA), and cannabichromonic acid (CBCA).
Through decarboxylation , CBGA is converted to CBG, which allows the cannabinoid to interact with cannabinoid receptors in the body. Research shows that CBG has partial affinity for CB1 and CB2 receptors . CBG can also stimulate receptors that affect pain, inflammation, and heat sensitivity .
CBG is usually present in low concentrations in most cannabis plants; however, breeding efforts have resulted in the creation of CBG-rich cannabis strains. CBG-dominant plants are known as "type IV" cannabis .
Although these cannabigerol-dominant plants are not yet widespread in the consumer hemp and cannabis markets, they are actively cultivated on a relatively large scale. Higher levels of CBG will allow extraction of the cannabinoid for therapeutic purposes.
WHAT IS CBD?
CBD is short for cannabidiol , a cannabinoid found in high concentrations in both type II (THC/CBD-predominant) and type III (CBD-predominant) cannabis and hemp plants.
CBD was first isolated from cannabis in the late 1930s and then neglected until the 1970s when scientists became interested in its anticonvulsant properties.
Since then, research has confirmed that purified CBD is an effective treatment for severe forms of childhood epilepsy. CBD may also have anti-inflammatory , analgesic , anti-anxiety , anti-nausea, and sedative properties.
In recent years, CBD has grown in popularity due to the many therapeutic benefits it provides. CBD can help alleviate some of the unwanted side effects of THC, such as anxiety, paranoia, and impaired cognitive function.
CBD in combination with THC appears to offer greater therapeutic benefits than either cannabinoid alone, a phenomenon known as the "entourage effect."
CBD acts on the endocannabinoid system through a variety of physiological pathways. It has partial affinity for CB1 and CB2 receptors, but also binds to several other receptors in the endocannabinoid system. Its mechanisms of action on the body are not yet sufficiently known.
What is the difference between CBG and CBD?
When consumed, CBG interacts with the human endocannabinoid system. This system consists of cannabinoid receptors (CB1 and CB2), enzymes and endocannabinoids (cannabinoids in the body).
This system is essential for maintaining optimal bodily function, i.e. for homeostasis. CBG binds to CB1 and CB2 receptors and exerts its inhibitory properties to stimulate a number of therapeutic effects on the user.
Structure of molecules:
The molecular structures of cannabigerol and cannabidiol differ. The number and arrangement of hydrogen, carbon, and oxygen atoms that make up a cannabinoid is called its molecular structure.
CBD and CBG have different three-dimensional shapes due to their dissimilar molecular structures and therefore bind differently to cannabinoid receptors in the body and act differently on the body.
The molecular structure of the cannabinoid also affects its bioavailability and degree of water solubility.
CBD and CBG activate receptors in different ways. A 2011 study published in Psychopharmacology, for example, compared the effects of CBD and CBG on the serotonin 5-HT1A receptor.
CBD appears to exert its anti-nausea effects by acting as an agonist (activator) of 5-HT1A receptors.
On the other hand, CBG acts as a 5-HT1A receptor antagonist (blocker).
The results revealed that CBG pretreatment blocked the anti-anaemic effects of CBD, suggesting that the two cannabinoids bind to the same receptor but have opposite effects on this receptor.
WHAT THERAPEUTIC EFFECTS OF CBG?
Although no clinical trials have been conducted to examine the effects of CBG in humans, a number of preclinical studies have provided insight into some of the potential therapeutic effects of CBG.
Although CBG does not give you an intoxicating psychoactive experience, it may provide other unique therapeutic benefits that may help with the conditions listed below, although further human trials are needed.
CBG its anti-bacterial powers:
According to a 2008 study, CBG is an effective antibiotic against methicillin-resistant staphylococcus aureus (MRSA). The antibacterial potential of 18 different cannabinoids, including cannabigerol, has been studied. CBG outperforms all other cannabinoids tested and is as effective as vancomycin , a powerful antibiotic.
Due to its ability to suppress abnormal cell proliferation, CBG has anti-cancer properties. By inhibiting the formation of melanoma cells on the skin of mice, research shows it has anti-tumor properties
CBG Anti-Inflammatory Properties:
In a 2013 study conducted on mice with induced inflammatory bowel disease, researchers administered CBG and examined various parameters related to inflammation.
The results showed that CBG increased the inflammatory response of mice by limiting the action of important inflammatory markers, such as IL-1, IL-10, INOS and interferon-γ.
The cannabinoid also reduces nitric oxide production and ROS (reactive oxygen species) formation in the gut. The scientists involved in the study concluded that CBG should be seriously considered in human experiments.
Neuroprotection and increased concentration
CBG promotes clarity and focus, which is one of the main reasons users seek out this cannabinoid. A 2014 study examined the neuroprotective properties of cannabinoids, including CBG, by administering the compounds to mice with induced Huntington's disease.
The results show that CBG has powerful neuroprotective properties that protect nerve cells in the brain from damage. The cannabinoid also helps improve motor deficits and contributes to 3-nitropropionic acid toxicity by preserving striatal neurons.
Promotes intraocular health
The ECS is located throughout the body, even in the eyes. It is responsible for maintaining eye health as part of homeostasis. Glaucoma is an eye disease that causes pressure inside the eye and interferes with vision.
A 1990 study published in the National Library of Medicine concluded that CBG has therapeutic potential to reduce intraocular pressure associated with glaucoma.
Emotional and mental health support
CBG does this in two ways. First, it suppresses the breakdown of GABA , a neurotransmitter responsible for producing a calming and relaxing effect. Second, CBG inhibits the reuptake of serotonin , a neurotransmitter that controls mood, pleasure, and sleep. With increased levels of serotonin and GABA in the body, optimal stress levels are maintained.
Vital in the treatment of pain and tension
CBG is a powerful pain reliever and muscle relaxant that helps relieve pain, muscle tension and discomfort. Pain management is the main reason people turn to cannabis products as an alternative to addictive and potentially deadly pharmaceutical drugs. Cannabigerol is a better pain reliever than CBD and THC due to its high affinity for ECS receptors.
It helps fight cancer cells.
A 2014 study in mice with colon cancer concluded that CBG plays an important role in reducing cancer cells and tumors, CBD + CBG and cancer read more
A recent study shows that CBG is an effective appetite stimulant with minimal side effects. This makes it a suitable choice for HIV patients and those undergoing heavy treatments such as radiation therapy and chemotherapy.
Cannabigerol is a promising cannabinoid that may offer a myriad of therapeutic benefits. Scientific research shows that CBG is a potentially potent pain reliever, muscle relaxant, neuroprotector, antibacterial, mood stabilizer, appetite stimulant, and anti-inflammatory agent.
Its full potential remains to be discovered as most scientific research is in its infancy. As research continues, the cannabinoid is guaranteed to provide many natural health benefits.
Where can I buy organic, safe and pure CBG?
At CBDTECH, we strive to create products that meet the health and wellness needs of consumers. We believe in making cannabis compounds, especially cannabinoids, accessible to everyone who needs them.
Therefore, we choose the best suppliers to offer innovative, pure and safe medical cannabis products to allow consumers to fully experience the benefits of the plant.