By Fabien, from the CBDtech team.
Imagine spending millions to optimize every minute of your life. This is the daily life of **Bryan Johnson**, an American technology entrepreneur obsessed with longevity. Recently, he took a step forward by integrating **psilocybin** (the active compound in “magic” mushrooms) into his protocol.
But Bryan didn't just "try": he measured everything. At CBDtech, we analyzed its results to understand what this means for you, who are interested in wellness and the science of psychedelics.
🔬 The Johnson Experience: A Macrodose Under Surveillance
Bryan Johnson took what's called a "macrodose" (a large dose) of psilocybin. The key information is that he performed extremely detailed blood tests before and after the experiment. Here are the three major results he shared:
- **Massive drop in Inflammation (over 35%!)**: His hsCRP level, a key marker of body inflammation, dropped to an undetectable level. This suggests that psilocybin may have a powerful **anti-inflammatory** effect.
- **Deep and lasting relaxation**: His cortisol level (the stress hormone) decreased by 42%. This "forced rest" of the central nervous system confirms the **stress regulation** effect often reported after a psychedelic experience.
- **Neuroprotective Effects**: Noted an increase in estradiol, a compound that has beneficial properties for the brain, including anti-inflammatory and **neuroprotective** effects.
To learn more about the mechanisms of psilocybin and its impact on cellular health, Bryan Johnson refers to cutting-edge scientific studies, such as this one:
—> **Link to the scientific study:** [Psilocybin treatment extends cellular lifespan and improves survival of aged mice](https://pubmed.ncbi.nlm.nih.gov/40628762/) (Pubmed study)
Watch Bryan Johnson explain his protocol himself:
✨ The Real Message for You: The Power of Microdosing
Bryan Johnson's experience is fascinating, but let's be clear: taking a macro dose is **not the right approach for a beginner**. Its protocol is unique, expensive and requires constant medical monitoring.
Fortunately, to benefit from these mechanisms (less inflammation, less stress, better mental well-being), you don't need a $2 million budget!
Microdosing: Your gateway to the benefits of Psilocybin
**Microdosing** involves taking very small amounts, so tiny that they are **imperceptible**. The objective is not to "trip", but to provide subtle and constant support to your system.
Microdosing acts on the **same mechanisms** that Bryan Johnson measured, but in a gentle and lasting way. This is the preferred approach for:
- **Improve mood and creativity** without upheaval.
- **Reduce daily stress** and anxiety.
- **Gain mental clarity** and concentration.
The fact that billionaires are now publicly validating the mechanisms that the microdosing community has been exploring for years? It’s simply science catching up with the wellness movement.
➡️ Continue your exploration with CBDtech
At CBDtech, we are convinced that natural substances offer incredible avenues for our mental health.
If you would like to learn more about the potential of psilocybin to alleviate daily challenges, including mental health issues, we invite you to read our dedicated article:
Psilocybin and mental well-being: Read our full analysis
We also recommend that you turn to our trusted partner, **Microdose Pro**, based in the Netherlands, whose geographical position and quality processes allow us to offer compliant products for the European Union.
🛑 Important Warning
This information is provided for educational purposes only and has not been evaluated by health authorities. Bryan Johnson's experiment involved a **macro-dose**, not recommended for beginners. The products and substances discussed are not medicines and in no way replace medical treatment. **Always consult a healthcare professional** before incorporating new substances into your routine and be sure to strictly follow the laws in force in your country.
