There depression, a global challenge relating to millions of people, requires an in -depth understanding to develop effective therapeutic strategies. A 2020 study Led by the eminent researchers of the Institut Pasteur, Inserm and CNRS illuminated an intriguing aspect: the imbalance of the intestinal microbiota, this bacterial community in our intestines, could play a crucial role. It seems that a disturbance at this level can cause a decline in metabolites linked to the depressive state. These results highlight the decisive influence of the intestinal microbiota on the brain and the role of CBD.
Intestinal microbiota: a key bacterial ecosystem 🦠
OUR intestine shelters a community sophisticated bacteria Who play a preponderant role in our well-being. As a main reservoir of bacteria in the body, the intestinal microbiota exerts a influence crucial on our health. Recent research highlights the beneficial interactions between the host and his microbiota, highlighting its impact on our emotional balance.
Obvious link between microbiota and mental well-being alterations 😌
Of the scientists of The Institute Pastor, of Cnrs and Inserm have established a tangible link between the intestinal microbiota and the effectiveness of antidepressants. Although the exact mechanisms of depression have long been enigmatic, a recent study offers clarification. She demonstrates how changes of microbiota, induced by a stress chronic, can contribute to the depressive state by causing a decrease in lipid metabolites in the blood and the brain. 🧠🔬
This notorious discovery strengthens our understanding of the complex links between our microbiota and our mental well-being, thus opening up new perspectives for the development of innovative therapies.
Intestinal microbiota: discovery of depression mechanisms 😊
THE metabolites lipidic in question are called cannabinoids endogenous, who bind to receiver present in the brain. These receivers are also the main target of THC / CBD, the active component of cannabis. Researchers discovered that when the Endocannabinoid system Dysfunction in a key region of the brain called the hippocampus, this leads to a depressive state.
© Pascal Marseaud
Study on microbiotas and mood disorders
To achieve these discoveries, the researchers studied microbiotes of healthy animals and animals with mood disorders. They observed that the simple transfer of microbiota of a animal depressive to one animal in Good health was enough to induce changes biochemicals and behavior associated with the state depressive at the latter. This demonstrates the close link between the intestinal microbiota and mood disorders.
Identification of bacterial species decreased in depressive animals
The researchers have identified certain bacterial species which are sharply reduced in animals with mood disorders. These observations suggest that these bacterial species could play a key role in the regulation of moods. On the other hand, the researchers also found that a treatment oral with these same bacteria allowed to restore a level normal of metabolites lipidic and thus treat the depressive state. This opens the way to new therapies based on the use of "psychobiotics", bacteria with antidepressant effects.
The role of CBD in the balance of microbiota😊
Some preliminary studies suggest that CBD can influence lipid metabolites and potentially contribute to their balance. Lipid metabolites, such as endocannabinoids, are involved in the regulation of various process physiological, including mood And inflammation in the brain.
THE Cannabidiol is known for interact With the Endocannabinoid system of the body, which includes receiver specific present throughout the body, including brain. Of the studies have shown that CBD can have effects on the production, release and metabolism of endocannabinoids.
However, it is important to note that research on the role of CBD in the balance of lipid metabolites is still limited and preliminary. The effects of CBD can vary from person to person. It is therefore essential to consult a health professional before starting any CBD treatment, especially if you already take medication or if you have underlying medical conditions.
Conclusion
The intestinal microbiota plays a crucial role in the functioning of the brain and the regulation of moods. Intestinal microbiota alterations can contribute to the development of mood disorders such as depression. However, using specific "psychobiotics", it is possible to restore a healthy microbiota and more effectively treat mood disorders. These discoveries open up new exciting perspectives for the development of innovative therapies in the field of mental health
Frequently asked questions:
1. What is the intestinal microbiota?
The intestinal microbiota, also called intestinal flora, is a set of microorganisms living in the digestive tract. It is mainly composed of bacteria, but also viruses, fungi and other microorganisms.
2. How does the intestinal microbiota influence the functioning of the brain?
The intestinal microbiota communicates with the brain through the intestine-end axis. The chemical signals produced by intestinal bacteria can affect neurotransmission and inflammation, thus influencing mood and behavior.
3. What are the mechanisms of depression linked to the intestinal microbiota?
Some researchers suggest that changes in the composition of the microbiota can lead to inflammatory processes and alterations in the signaling of neurotransmitters, thus contributing to the development of depression.
4. What is endogenous cannabinoids and what is their role in depression?
Endogenous cannabinoids, such as anandamide, are compounds produced naturally by the body. They influence the endocannabinoid system, which regulates various physiological processes, including mood. Dysfunctions in this system can be associated with depression.
5. How can "psychobiotics" help treat mood disorders?
Psychobiotics are specific probiotics that can have a positive impact on mental health. By promoting the balance of the intestinal microbiota, they can modulate the chemical signals between the intestine and the brain, potentially improving the symptoms of mood disorders. However, research is still underway to determine their precise efficiency.
