Psilocybin, a molecule present in psychedelic or hallucinogenic fungi, could be more effective than conventional antidepressants, according to a study published in the journal Nature Medicine.. This significant increase is not surprising, due to the general lack of social contacts, stress at work, stress linked to housing and other factors that people now have to face because of the virus.
While the rate of depression continues to increase, scientists are looking for more and more new ways to deal with this mental problem. A team of theImperial College of London Recently tested psilocybin, a controversial psychedelic drug, as a treatment option, with surprising results.
Update 3/09/2023
Jimmy Mohamed is a well -known French doctor. He is often present in the French media, where he shares information and advice on health and medicine. As a health professional and his presence on YouTube, he gives different advice in video For the treatment of depression such as hallucinogenic mushrooms with psilocybin.
Therapy assisted by psilocybin: a promising treatment for depression
Clinical depression is a debilitating mental illness that affects millions of people around the world. Conventional treatments, such as antidepressants, can take weeks, even months, to show results, and are not effective for everyone. However, a new study Published in the Jama newspaper offers renewed hope for people with depression. This study explores the use of psilocybin, the active compound of magic fungi, as a potential treatment for depression. In this article, we will examine the results of this revolutionary study and what it could mean for the future of the treatment of depression.
The study and its participants
The study, published in the Jama newspaper, focused on 104 adults diagnosed with at least moderate clinical depression. The participants were randomly distributed in two groups. The first group received a single dose of 25 milligrams of psilocybin, while the second group received niacin, used as placebo. Niacin was chosen because of its temporary effects on the body, such as skin redness, which made it difficult for participants to determine which group they belonged to. The two groups also followed several therapy sessions to support treatment.
Amazing results
Participants of the two groups were followed for 43 days, or about six weeks. At the end of the study period, the researchers made a remarkable discovery. Psilocybin, associated with therapy treatment, has shown a "fast and sustained antidepressant effect". Participants who received psilocybin reported significantly lower depression levels compared to the placebo group, according to a standard measurement scale. In addition, the improvements observed seemed to last longer in those who had taken psilocybin. In addition, the Psilocybine group has declared a clear improvement in their daily operation and their global quality of life. Although there has been a higher rate of undesirable events in the Psilocybine group, no serious event linked to treatment has been documented, according to the authors.
The implications of the study
It is important to note that phase II trials cannot provide definitive evidence of the effectiveness of a drug or treatment. However, these results are added to the growing evidence that psilocybine assisted therapy could be a promising option for people with depression. A similar phase II study carried out previously had already shown a significant reduction in the symptoms of depression in patients resistant to treatments after having taken a single dose of psilocybin, with psychological support.
The authors of the latest study said : "These results are added to the growing evidence that psilocybin, when administered with psychological support, can be promising as a new intervention for depression." These promising results prompted to launch a large -scale phase III test on the therapy assisted by psilocybin this year. If the results of these trials are positive, they could provide the necessary evidence so that regulators formally approve the psilocybin as the treatment of depression. At the same time, researchers also explore the use of psilocybin for other conditions, such as disorders linked to alcohol consumption. In the United States, efforts are underway to legalize the medicinal use of psilocybin.
Conclusion
In conclusion, the results of this study on the therapy assisted by psilocybin offer considerable hope for people with clinical depression. Although additional research is necessary to confirm these results, existing evidence suggest that psilocybin, in combination with psychological support, could become a viable option for the treatment of depression. This advance in the field of mental health is promising and offers a glimmer of hope for those who fight against this debilitating disease.
Faqs
What is psilocybin?
Psilocybin is the active compound found in magic mushrooms. It is known for its psychedelic effects and could have therapeutic potential to treat depression.
What are the advantages of therapy assisted by psilocybin in relation to conventional treatments?
Psilocybine assisted therapy seems to offer faster and lasting results for patients with depression, compared to traditional antidepressants.
Are there side effects associated with psilocybin?
Yes, there may be side effects, such as temporary physical sensations and undesirable events. However, they seem to be manageable and not serious.
How long does it take to feel the effects of psilocybin?
According to the study, the antidepressant effects of psilocybin were observed quickly, in a few weeks.
Where are research on psilocybin as a treatment for depression?
Research is progressing, and phase III tests are underway. If the results are positive, that could open the way for official approval of psilocybin for the treatment of depression.
"It would seem that psychedelic substances are mistaken in the drug list."
If psychedelics are still prohibited in France, more and more scientists are studying their benefits. Their active ingredient, deemed without dependence, could help in care against depression, smoking, alcoholism or even neurodegenerative diseases like Alzheimer's. Video explanations in Michel Cimes' show
Psychedelics, drugs of the future? The extraordinary powers of the human body:
Psilocybin in the treatment of depression
Earlier in 2022, researchers Johns Hopkins University could show that psilocybin is capable of treating some of the symptoms of major depressive disorder in adults for up to a month. However, this experience was closely controlled and the researchers stressed that other tests were necessary to establish psilocybin as an effective treatment.
In addition, Food and Drug Administration (FDA) will have to fully authorize the use of drugs for commercial purposes. Since psilocybin gives consumers psychedelic effects, such as hallucinations, this can take some time before this drug is taken by the health care community. However, researchers continue to study it in the hope of helping to confirm its advantages.
An improvement in brain connection
In their own experience, researchers from the Imperial College of London have carried out irmf analyzes from nearly 60 participants in their study. All patients have received psilocybin as well as speech therapy sessions. Brain scintigraphs were carried out throughout the study to describe the effect of the drug on the brain.
In their analysis, the researchers have found an increase in brain connectivity, especially between the different parts of the brain, which are more isolated in patients with depression. This brain connection has allowed many patients to "open up" more during treatment and to feel a certain relief of symptoms. The researchers discovered that these advantages lasted up to three weeks after that, which means that the drug considerably improves the disorder. Researchers have published their discoveries in Medicine nature.
Psilocybin for other pathologies?
Although researchers are hopeful about the advantages of this medication, they know that more research is necessary. According to Robin Carhart-Harris, principal author and professor at the University of California, "We have not always known for how long these changes in brain activity" have been observed with psilocybine therapy, and we have to do more research to understand this. "Although research is still in progress, researchers think that the advantages of psilocybin can be transferred to other mental health problems, not just depression"
We have discovered a fundamental mechanism by which psychedelic therapy works not only in depression but also in other mental illnesses, such as Anorexia or the dependence To alcohol, tobacco ... ", added Carhart-Harris.
Which hallucinogenic fungus take?
Mushrooms containing psilocybin and psilocin are generally of the genus Psilocybe, Panaeolus and Copelandia and there are more than 50 species. Amanite Tue-Mouches (Amanita Muscaria) can also be used but it is particularly dangerous for health.
Which Growkit to choose?
The 1st place returns to this variety of magic mushrooms.
Of unknown origin, the Golden Teacher is distinguished from other hallucinogenic mushrooms by its particular appearance.
This culture kit Contains the psilocybe fungus cubensis "golden teacher", known for its didactic effects and its unknown origin.
The Golden Teacher is known for its golden hats and special shamanic capacities and is very popular due to its easy and quick growth.
With this strain, the first harvest is often the smallest, the second is generally much greater.
Due to the quality of the fungus, The active ingredient content is much higher to that of most traditional market kits on the market.
Buy a magic mushroom kit?
Golden Teacher strain
This cultivation kit contains the psilocybe cubensis "golden teacher" fungus, known for its didactic effects and its unknown origin. The Golden Teacher is known for its golden hats and special shamanic capacities and is very popular due to its easy and quick growth.
With this strain, the first harvest is often the smallest, the second is generally much greater. Due to the quality of the fungus, the active ingredient content is significantly higher than that of most traditional market kits on the market.
In the box
Inside the box you will find:
1200 ml culture box
1 culture bag
2 trombones
Magic mushroom kit
Do you want to cultivate your own magic mushrooms for microdosage?
With the microdose pro culture kit, you can cultivate your own magic mushrooms in three weeks.
The Culture Kit Mushroom Psyl CARLOPIBIN:
- is perfect for microdosage
- will give at least 2 harvests
- will produce fresh magic mushrooms within three weeks
- Understands our culture manual
Important : Keep the culture kit in the refrigerator after delivery. Expiration date after a month.
Learn more
What is a truffle?
To understand why magic truffles have remained legal, we must first understand what they really are.
And, of course, how they differ from magic mushrooms.
We mainly talk about truffles in the Netherlands because they are not allowed in most other countries. During their visit to Amsterdam, many are surprised by the ease with which it is possible to buy truffles.
They can be purchased in chic cafes and shops and are generally presented in colorful packaging with names such as: "Mexicana", "Atlantis" and "High Hawaiians"
But what are the truffles exactly?
Magic truffles have nothing to do with the types of truffles that we know in the kitchen.
THE magic truffles are sclerotes, which are essentially a hard mass of fungal mycelium growing below the surface.
Magic truffles come from the fungus mycelium psilocybe and contain psilocybin. Psilocybin is a compound hallucinogenic and gives to truffles and mushrooms a psychedelic effect.
All the information contained in this article is based on sources and references, and all the opinions expressed are mine. I do not give advice to anyone and although I am happy to discuss subjects, if someone has another question or concern, he should ask for advice from a competent specialist. People who suffer from psychiatric, neurological or cardiovascular disorders or who use psychiatric drugs should completely avoid microdosage
