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New study on microdosing psilocybin shows promising results

New study on microdosing psilocybin shows promising results

You know, sometimes it's when you see the small steps that you realize how big you can be. And speaking of small steps, let's enter the world of microdosing, where size doesn't really matter, but impact does!

Today, buckle up (or don't, it's pretty relaxed around here), because we're going to dive into a new study published in Nature . And no, it's not a study of how ants deal with daily stress, but something just as captivating: microdosing psychedelics.

https://www.nature.com/articles/s41380-023-02280-z

Now I know what you're thinking: "Can these small doses really cause significant changes?" Well, dear curious friends, prepare to be amazed!

It will shake up your perception of the world, and maybe even your perception of microdosing psychedelics . 🚀

Study on Psilocybin Microdosing

The most recent study on microdosing, published in Molecular Psychiatry by Nature, offers an exciting insight into the possibility of making our lives a little less crazy. 🌱 Who would have thought that the answer to our problems was in a mushroom?

We now wonder if this little something could be the key to coping with daily stress . Just imagine: a pinch of microdosing to recalibrate your emotional compass. 🧭 That would make stress management a piece of cake, right?

But wait, these aren’t just philosophical musings! The practical implications of this discovery are as real as your morning coffee. Science is evolving by leaps and bounds, and with each study, we get one step closer to understanding these micro-brain interactions that could trigger major improvements in our daily lives . 🚀

And now, the latest juicy news on the subject!

Intrepid researchers dove headfirst into the world of microdosing with a well-controlled animal model. They hope to demystify the secrets of microdosing that might just be the key to happiness (or at least stress management). 🐭✨

In this study, they used rats as test animals and gave them psilocybin in low doses , comparable to a microdose for humans, every other day for 21 days . Here's what they discovered:

  • Tolerance : The rats tolerated low doses of psilocybin remarkably well, with no signs of anhedonia, anxiety, or changes in movements – crucial markers since they are similar to those we use to assess human responses.
  • Stress resilience : Microdosing appears to fortify rats against stress, a glimmer of hope for what could translate to human experiments.
  • Behavioral Changes : The frequency of behaviors similar to human compulsions decreased significantly, hinting at psilocybin's potential to alleviate certain repetitive and potentially distressing thought patterns.
  • Biological changes : Beyond behavior, the study found an increase in 5-HT7 receptor expression and synaptic density in the paraventricular thalamic nucleus, indicating enhanced neuronal connectivity.

Now this last part deserves special attention, so let me explain it to you in a humorous way:

Let's talk synaptic density , the Paris of brain signals. Imagine yourself in the middle of information traffic, where the synapses are the roundabouts where people honk their horns. Well, microdosing psilocybin is a bit like having a super city planner in this cranial metropolis. More intersections , fewer traffic jams , and smoother communication than the latest tube of the moment.

And guess what? Rats, these anonymous heroes of research, showed increased resistance to stress after their treatment of miniature magic mushrooms. The paraventricular thalamic nucleus , Ali Baba's cave of stress in rats, got a makeover thanks to microdosing . Result: less stress , more coolness.

Conclusion :

Some skeptical minds say: “Well, there’s nothing there!” They point to studies that compared microdosing to a placebo and found nothing crazy in terms of mood, attention, or creativity.

But these studies are often questionnaires and lab tests. Like, seriously, like you could encapsulate the whole experience into a little check box. Maybe they're missing the nuances of real life, you know?

And there, drum roll, a new study arrives, with its controlled atmosphere and its physiological side. She tells us that microdosing isn't just a placebo thing, it's serious, it even affects brain chemistry. 🧠

Of course, we are not yet at the universally accepted microdosing party. There are still steps to climb, research to be done (especially on real humans, not just on mice that look lost).

But each study is like a USB key of knowledge that we push into the port of understanding. It’s progressing, little by little.



Want to dive into this strange world of microdosing? Curious like a cat in front of a cardboard box? So let’s explore the depths of the brain together! 🚀

Microdosing FAQ:

Is microdosing safe?
According to preliminary studies, microdosing appears to be well tolerated and without serious adverse effects. However, it is always recommended to consult a healthcare professional before beginning any microdosing practice.

What substances are commonly used for microdosing?
The most common substances used for microdosing are psilocybin (found in magic mushrooms or truffles) and LSD. However, it is important to note that their use must be done responsibly and legally.

What are the expected effects of microdosing?
Users report effects such as improved mood, creativity, concentration, and reduced stress and anxiety. However, the effects may vary from person to person.

How do you determine the right dose for microdosing?
The recommended dose for microdosing is generally sub-perceptible, meaning it does not produce significant psychedelic effects. It is recommended to start with a very low dose and gradually adjust according to individual responses.

Is microdosing legal?
The legality of microdosing depends on the substance used and the country's laws. In some places, microdosing substances like psilocybin and LSD is illegal, while in other places it may be tolerated or even legal in a medical or research setting.

Can microdosing be used to treat mental health disorders?
Although preliminary studies have shown promising results, microdosing is not yet an approved practice for the treatment of mental health disorders. It is important to consult a healthcare professional for any medical condition.

What are the potential risks of microdosing?
Although microdosing is generally considered safe, there may be potential risks such as adverse reactions, drug interactions, and worsening mental health in some people. Responsible use and medical supervision are essential.

How do I find a microdosing community?
There are several online and offline communities dedicated to microdosing. You can join microdosing-related forums, discussion groups, or events to share experiences and get advice.

Is microdosing recommended for everyone?
Microdosing is not recommended for everyone. It is important to consider individual physical and mental health, medical history, and current medications before deciding to microdose. A medical consultation is always recommended.

Is there research on microdosing in fields other than psychology?
Although most research on microdosing focuses on its psychological effects, there are also studies exploring its potential in other areas, such as creativity, productivity, and improved cognitive performance. However, these areas still require in-depth research.

All information in this article is based on sources and references, and all opinions expressed are my own. I do not give advice to anyone and although I am happy to discuss topics, if anyone has any further questions or concerns they should seek advice from a competent specialist. People who have psychiatric, neurological, or cardiovascular conditions or who use psychiatric medications should avoid microdosing completely.


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