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CBD and cystic fibrosis, can cannabidiol help?

CBD and cystic fibrosis, can cannabidiol help?

Clinical interest in cannabis and CBD is growing, and data on its healing power continues to accumulate. As scientists learn more about this fascinating plant, unexplored possibilities for its therapeutic potential are being revealed.

CBD even has the potential to relieve some of the symptoms of cystic fibrosis. The testimonials are way ahead of the scientific data, but it seems that CBD can help improve the quality of life for over 70,000 people worldwide living with this debilitating disease.

What is Cystic Fibrosis?

Cystic fibrosis, also known as cystic fibrosis, is a progressive, lifelong disease in which the body produces thick, sticky mucus that builds up in the lungs and digestive system.

It is caused by a genetic defect in the CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) protein.

The main symptoms are:

  • Lung infections
  • Cough, wheezing, shortness of breath
  • digestive problems - abdominal pain, constipation, diarrhea
  • Lack of appetite and weight loss

It is an extremely debilitating disease for which no cure is known. In the past, people with cystic fibrosis did not live to school age.

Medical advances mean that patients are already living much longer, with the life expectancy of children born with cystic fibrosis now exceeding 50 years.

Treatment for cystic fibrosis usually involves inhaled medications such as antibiotics, steroids, and enzyme preparations. There are also therapies to remove mucus from the lungs and expand the airways.

But in the search for new ways to improve the quality of life for people with cystic fibrosis, CBD may offer invaluable potential.

Video understanding cystic fibrosis:


What is CBD?

CBD, abbreviated cannabidiol, is a natural cannabinoid found in the Cannabis sativa plant. It is non-psychoactive, which means that CBD is devoid of the "intoxication" caused by the cannabis molecule, tetrahydrocannabinol (THC). Both cannabinoids - CBD and THC - have been shown to have powerful therapeutic effects when used alone or in combination.

Cannabinoids interact with our endocannabinoid system (ECS) – a complex network of cellular signals in our body that helps regulate mood, immune function, appetite, sleep, memory, pain and more.

CBD can indirectly modulate the function of our cannabinoid receptors, which can be found anywhere in the brain and body – including the airways .

Can the therapeutic properties of CBD help people with cystic fibrosis?

As early as 2002, an article published in the Journal of Cannabis Therapeutics detailed the theory that cystic fibrosis causes endocannabinoid deficiency and "by increasing these levels, symptoms may be improved".

CBD indirectly increases levels of anandamide an endocannabinoid naturally produced in the body.

In this way, CBD can complement ECS and subsequently improve CF symptoms.

Following the publication of this article, the effect of THC has been positive in animal models of cystic fibrosis, but CBD remains largely unexplored.

However, there is evidence that CBD can reduce pain and inflammation , support the immune system , and alleviate gastrointestinal issues in a myriad of other clinical conditions.

CBD won't be a cure for cystic fibrosis , but in theory it can help relieve some of the symptoms without the nasty side effects of existing medications - and here's how:

  • CBD Can Reduce Inflammation:

CBD is a powerful anti-inflammatory effect. Numerous experimental and clinical studies have shown that it reduces inflammatory pain and reduces the severity of the inflammatory response. Inflammation is a major driver of cystic fibrosis symptoms, so CBD can help relieve inflammation and inflammatory pain in the lungs and digestive system in patients with cystic fibrosis.

  • CBD can reduce Nausea
Due to the digestive discomfort and loss of appetite that accompanies cystic fibrosis, patients with cystic fibrosis may experience difficulty absorbing enough nutrients and maintaining a healthy weight. Due to its ability to stimulate the appetite, cannabis is a well-known appetite stimulant. CBD has also been shown to suppress nausea in animal models, suggesting that CBD may help people with cystic fibrosis who have difficulty eating.

  • CBD helps reduce anxiety

Cystic fibrosis (CF) is an extremely debilitating and isolating disease that can cause anxiety or depression in many patients and their families. Where CBD outshines other pain relievers is its ability to support our mental health. By interacting with serotonin receptors in the brain, CBD can help signal the "happiness hormone" - serotonin. This is believed to be why CBD relieves anxiety and depression, as shown in various studies in human and animal models.

Is there any evidence for the benefits of CBD?

Currently, the only evidence supporting the use of CBD or cannabis to treat CF symptoms is anecdotal. In an article on Cystic Fibrosis News Today , Brad Dell, who has tried both cannabis and CBD to relieve some of the symptoms of cystic fibrosis, wrote that CBD "didn't work so well for my appetite, [but ] it helped open up my airways,” reducing pain and relieving nausea. I even hiked with supplemental oxygen. "

Although there is no experimental evidence for the effectiveness of CBD in cystic fibrosis, some evidence supports the use of CBD to reduce inflammation and open bronchial airways in animal models of lung infections.

There is also growing evidence to suggest the use of CBD to control symptoms of inflammatory bowel diseases, such as Crohn's disease.

Although the clinical manifestations of cystic fibrosis differ from those of other lung and inflammatory diseases, these results suggest that CBD may help alleviate the various symptoms of cystic fibrosis and indicate areas for future research.

No clinical trial data is available at this time. Although many people choose to self-medicate with cannabis products, there is not enough evidence to support their safety or effectiveness in treating CF symptoms.

Is the use of CBD safe?

As a dietary supplement, CBD is considered safe and well tolerated. There is also plenty of data showing the safety of CBD for use in other medical conditions, including epilepsy.

Although some review articles illustrate several areas of CBD's safety profile that remain to be explored, such as its interactions with other medications.

CBD side effects are rare and mild. These can include nausea, fatigue, and changes in appetite. This is obviously a potential contraindication to using CBD to treat cystic fibrosis, as appetite and digestive issues are common symptoms.

Although the side effects of CBD are usually eliminated with the right dose, so start low and increase gradually.

How to Take CBD for Cystic Fibrosis

There is no definitive answer as to how much CBD to take for cystic fibrosis (cystic fibrosis) or how to take it. It's all a matter of personal preference. For example, you can try a full-spectrum CBD product – as close to cannabis as possible – to take advantage of the entourage effect .

There are countless ways to consume CBD and hundreds of products. Some CBD testimonials report the use of inhalers and vaporizers to soothe inflamed lungs, but others prefer to choose CBD oils for consumption to avoid further respiratory irritation.

Here are some of the ways to take CBD for cystic fibrosis:

CBD oil

Oils are one of the most popular ways to take CBD. By placing a few drops under the tongue, CBD quickly enters the bloodstream and has a rapid onset of action. It's an effective way to get the dose you need and you control how much you take.

CBD in Capsules

CBD can also be consumed in capsule form. They usually come in different strengths which are a great option for a consistent daily dose. Since CBD must pass through the digestive system, this method can be beneficial for the digestive issues that many people with CF face.

But keep in mind that the capsules must be taken with food for the CBD to be properly absorbed.

When choosing a CBD product, there are many other things to consider: dosage, effectiveness, traceability, other ingredients - the market is confusing. For more information, see our CBD blog.

Researchers can't say for sure if CBD can improve CF symptoms; Clearly, science still has a long way to go, but even outside of the clinical realm, CBD appears to be a powerful daily supplement. By supporting our mental and physical well-being, CBD can help improve the quality of life for thousands of people - definitely worth a try.

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