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Paracetamol / Opioid calms all pain?

Paracetamol / Opioid calms all pain?

In the midst of the opioid epidemic, where opioid overdose deaths continue to rise, an interesting trend has emerged. States that have legalized cannabis have seen declines in opioid-related emergency room visits and prescriptions. This begs the question: could cannabis offer prospects for pain management and reduce the need for opioid painkillers?

Paracetamol helps calm your pain: reality or placebo effect?

Its “magical” powers will eliminate the mind-numbing concert of percussion that resonates in your head with the snap of a finger.

Any excuse is good to swallow this thick, pearly white tablet in one go!

Are there any risks in overconsuming Paracetamol? 💊

Very (too?) frequently prescribed, paracetamol occupies a special place in the therapeutic arsenal. In medicine, “classic” pain treatments are divided into 3 levels. Like a staircase, we go up floor by floor until the pain stops (the 3rd floor corresponds to the morphine derivatives - #Bazooka). At the first level we find our beloved paracetamol and anti-inflammatory drugs.

How does it work?

Well, uh, how can I put it... We've been using it for almost a century, but we don't yet have all the elements to explain its properties in detail. It appears that paracetamol acts within the central nervous system by inhibiting the production of prostaglandins.

This molecule is involved in pain transmission and inflammatory mechanisms. This gives rise to two main effects: an antipyretic (antipyretic) effect and an analgesic (pain-relieving) effect.

Is there a risk ?

"I read in the brochure that even pregnant women can take paracetamol in case of pain. So it's safe, right?"

Although paracetamol has excellent tolerance compared to other medications, it still risks causing side effects, sometimes serious, when taken in excess. Degraded by enzymes, a sort of "molecular scissors", paracetamol transforms into a toxic product (NAPQI) when it passes through the liver .

Under normal circumstances, the latter is eliminated by the body without presenting any danger. However, if you take too much (estimated at 8 to 10 grams , or an entire box of Doliprano), the body can no longer keep up. Toxic products accumulate and cause liver cell death . This can have very serious consequences and sometimes requires a liver transplant.

⚠️ Thus, it is easier to understand the limit of 4g per day imposed in the brochure and the minimum time of 4 hours between 2 doses (time to eliminate the toxic product).

High consumption of nonsteroidal anti-inflammatory drugs (NSAIDs) and other over-the-counter pain relievers is associated with an increased risk of kidney disease (ibuprofen) and stomach problems (acetylsalicylic acid) . Even painkillers, like acetaminophen, if used excessively and in combination with alcohol, can lead to liver problems .

Given all of this (combined with the devastation that pharmaceutical companies have left with their aggressive marketing of opioids),

one wonders why no one jumped on Marilyn Barrett's original cannflavin discovery in the 1980s.

Flavonoids are compounds produced by many plants that influence, among other things, the color of flowers. Beneficial for the plant (attract a pollinator, inhibit the growth of mold, etc.)

In the 1980s, Dr. Marilyn Barrett identified two flavonoids in Cannabis CBD that were previously unknown. She named them “ Cannflavin ” A and B.

In 2013, Mahmoud ElSohly and colleagues at the University of Mississippi identified a third, Cannflavin C.

Cannflavins are currently being studied for their anti-inflammatory activity,

Barrett's team had discovered that Cannflavin was 30 times more potent than aspirin in the cell culture test,

Copy of Cannflavin c. Aspirin

This finding was echoed in the synovial cell test, in which cannabinoids stimulated the production of PGE2 and Cannflavin had an inhibitory effect .

The principle of operation of the endocannabinoid system is to maintain homeostasis . CBD reduces pain activators by promoting homeostasis, which reduces the release of the inflammatory substance.

How Opioids Work

Our body has a built-in opioid system that helps manage pain. Opioids, such as endorphins , are chemicals released in response to stress or pleasurable activities. Morphine, a natural opioid derived from the opium poppy, was discovered to be very effective in relieving pain in the 19th century. Since then, synthetic opioids such as hydrocodone and oxycodone have been developed for pain relief.

Opioids work by binding to specific receptors in the body, particularly the mu-opioid receptor found on nerve cells transmitting pain along the spinal cord. Activation of these receptors reduces the ability of cells to transmit painful information to the brain. Opioids also bind to receptors in the brain, causing the release of dopamine, the so-called "feel-good" chemical, which contributes to their addictive potential.

However, prolonged use of opioids leads to tolerance , where the body adapts by turning off the receptors. This requires higher doses of opioids to achieve pain relief and the desired effect, thereby increasing the risk of overdose .

Medical Cannabis to Reduce Opioids

benefits of cannabinoids

Studies show that medical cannabis can be used to relieve chronic pain and replace opioids, which may reduce the risk of overdose and illicit drug use. In this study, researchers analyzed data from 8,000 participants to assess the effect of medical cannabis use on opioid use.

Results showed that patients who used medical cannabis for a longer period reduced their opioid use by an average of 48%, while those who used medical cannabis for a shorter period reduced their opioid use by only 4%.

The researchers concluded that medical cannabis could indeed replace opioids in the treatment of chronic pain. Some patients even reduced their opioid use by 50% after 8 months of medical cannabis use.

Strong painkillers ( opiates ) are known to be addictive, with considerable health risks. Two recent studies suggest that its use may be associated with overweight and obesity.

Opioids are powerful analgesics derived from opium: morphine, codeine, oxycodone, tramadol, fentanyl... They can only be purchased with a prescription.

Initially, these medications were indicated for severe pain, but were gradually prescribed for moderate pain. Beyond the side effects of these medications (constipation, nausea, drowsiness, etc.), one of the main problems is dependence and the risk of overdoses (intentional or accidental), which can lead to coma and death.

CBD is becoming very popular due to its analgesic and anti-inflammatory properties. It is capable of relieving certain chronic neuropathological or muscular pain. It can very well replace aspirin or paracetamol. In addition, know that this product is capable of relieving certain health problems, such as migraine , diabetes , liver problems, cardiovascular disorders. It is also in high demand among athletes, because it helps them recover well after intense physical effort.

In short, taking Cannabidiol , a product with many health benefits , is legal in the treatment of mental disorders, insomnia and pain. The method of consumption (inhalation, herbal tea, CBD oil , etc.) varies depending on your objective. Please note that it is now possible to order CBD online or in specialized stores .

population open to medical cannabis

Exploring the combination of cannabinoids and opioids

Researchers are currently investigating the potential of combining THC and CBD with existing opioids for pain management. Studies in animal models and humans aim to understand the benefits, such as increased pain relief, as well as the risks, primarily the potential for addiction and overdose. Preliminary results suggest that combining cannabinoids and opioids could reduce the dose of opioids needed for effective pain relief, which could potentially reduce the risk of addiction and overdose.

However, it is important to note that research into the combined use of cannabinoids and opioids in pain management is still in its early stages. Studies are limited and results are variable. Additionally, there are concerns about the interaction between the two substances, particularly regarding adverse side effects and increased risk of sedation and respiratory depression.

Despite these limitations, many patients report effective pain relief when using both cannabinoids and opioids, warranting continued research in this area.

Interesting Study Reveals Patients Prefer CBD Over Medication

It's no secret that pharmaceutical industry products kill a large number of people around the world every year.

In fact, the World Health Organization estimates that in 2017 alone, more than 115,000 people died from opioid overdoses.

This does not mean that all pharmaceutical drugs are harmful in all cases for every patient. Honestly, some prescription medications help some people.

However, pharmaceutical companies and the rest of the medical industry greatly encourage the use of pharmaceuticals, which causes much suffering and unhappiness.

At the same time, the much safer cannabis plant remains banned in most parts of the world.

Patients replacing pharmaceuticals with cannabis
A team of Dutch researchers recently conducted a study of more than 2,800 medical cannabis patients on the European continent.

The aim of the study was to assess how often patients replace medical cannabis with prescription medications.

According to the survey, 56% of participants reported replacing pharmaceutical medications with medical cannabis.

The most common types of prescriptions that replaced medical cannabis were opioids, antidepressants, and arthritis medications.

Safer medicine

As the researchers' findings show, cannabis is a better medicine than pharmaceuticals, if only because it does not have as many side effects.

Side effects in medications can range from skin rashes to death, and there are many other side effects.

On the other hand, cannabinoids have never, in human history, caused the death of a person. According to all indications, this is a safe and effective drug. As always, talk to your doctor to find out if cannabis is right for you.

source site

Conclusion

Overall, cannabis shows exciting potential as an alternative to opioid analgesics for pain management. Cannabinoids, such as THC and CBD, have shown promising results in pain relief and may also have beneficial effects on other medical conditions.


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